Symposia Sessions

Monday, October 15, 2012, 3:30 pm – 5:00 pm
SYMPOSIUM #1   PGC Cross Disorder and Pathway Analysis Group: Results from SNPs to Pathways
Chair/Discussant: Gerome Breen; Co-chair: Peter Holmes

-Update on PGC Cross Disorder Analysis, Stephan Ripke
-Network and Pathway Analysis for Deciphering the Pathogenetic Role of MicroRNAs in Psychiatric Disorders, Phil Hyun Lee
-Combined Pathway Analysis from PGC Cross Disorder Datasets, Gerome Breen
-Genomic Partitioning by Functional Annotation of Variance and Covariance Explained by SNPs, Sang Lee

SYMPOSIUM #2   Next Generation Sequencing in Schizophrenia
Chair: George Kirov; Co-chair/Discussant: Shaun Purcell

-Seeking De Novo Mutations in Schizophrenia by Whole Exome Sequencing of 600 Trios, Michael O’Donovan
-De Novo Mutations in Neurodevelopmental Disorders, Guy Rouleau
-Sequence Analysis of Schizophrenia and Autism Spectrum Disorders in the UK10K Project, Aarno Palotie
-Whole-exome Sequencing in 5000 Swedish Schizophrenia Patients and Matched Controls, Shaun Purcell

SYMPOSIUM #3   Genetics of Imaging and Neuro-cognitive Phenotypes and their Relevance as Genetic Endophenotypes for Psychiatric Disorders
Chair: Stephanie Le Hellard; Discussant: Vidar Steen

-TCF4 Sequence Variants and mRNA Levels are Associated with Neurodevelopmental Characteristics in Psychotic Disorders,  Ole Andreassen
-Systematic Search for Genetic Factors Influencing the Thickness of the Cerebral Cortex, Sven Cichon
-ENIGMA: Enhancing Neuro-imaging Genetics through Meta-Analysis, Sarah Medland
-Polygenic Deconstruction of Psychiatric Disorders with Neuro-cognitive Gene Sets, Stephanie Le Hellard

SYMPOSIUM #4   Epigenetic Factors Influencing Neuropsychiatric Phenotypes and Disorders
Chair: Melanie Carless; Co-chair/Discussant: Jimmy Potash

-Genetic and Epigenetic Regulation of Schizophrenia Associated MicroRNA, Murray Cairns
-Combined Genetic Analysis of DNA Methylation and Gene Expression in Schizophrenia Identifies Disease Susceptibility Loci, Roel Ophoff
-Methylomic Profiling in Autism Spectrum Disorder, Chloe Wong
-Allele-specific DNA Demethylation in FKBP5: A Molecular Mediator of Gene X Environment Interactions with Childhood Trauma, Torsten Kengel

Tuesday, October 16, 2012, 3:00 pm – 4:30 pm
SYMPOSIUM #5   Using Next Generation Sequencing to Unravel the Etiology of Mood and Psychotic Disorders
Chair: Dick McCombie; Co-chair: Fernando Goes; Discussant: Aiden Corvin

-Next Generation Sequencing of the DISC1 Locus in Major Mental Illness and Cognition, David Porteous
-Family Studies of Psychiatric Disorders, Dick McCombie
-Exome Sequencing of Familial Bipolar Disorder, Fernando Goes
-Whole-exome Sequencing in Swedish Bipolar Disorder Patients and Matched Controls, Pamela Sklar

SYMPOSIUM #6   Immunogenetics of Affective Disorders and Cognitive Function
Chair/Discussant: Bernard Baune; Co-chair: Sarah Cohen-Woods; Discussant: Peter McGuffin

-Immune System in Emotion and Cognitive Processing, Bernard Baune
-Immune System in Neuroimaging, Udo Dannlowski
-Molecular Aspects of the Immune System in Depression, Patricia Zunszain
-Childhood Stress-Reactivity and Inflammatory Mechanisms in Clinical Major Depressive Disorder, Sarah Cohen-Woods

SYMPOSIUM #7   From GWAS Signals to Neural Mechanisms: Neurocognitive, Neuroimaging and Cellular Approaches to Characterizing the Functional Effects of Psychosis Risk Variants
Chair: Gary Donohoe; Co-chair/Discussant:  Katherine Burdick

CSMD1 Genome-wide Associated Risk Variant For Schizophrenia: Effects on Brain Function and Structure, Gary Donohoe
-The Neural Basis of Polygenetic Risk to Bipolar Disorder, Andrew McIntosh
-Molecular Mechanisms of the Schizophrenia Susceptibility Gene TCF4, Matthew Hill
-Functional Effects of Two Different ANK3 Alleles Associated with Psychosis, Sophia Frangou

SYMPOSIUM #8   Practical, Societal, Ethical, and Legal Challenges for Modern Biobanking and Brainbanking
Chair: Thomas Schulze; Co-chair: Peter Falkai; Discussant: Marcella Rietschel

--The “DGPPN – Cohort Study” – A National Initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for Establishing a Large-scale Cohort of Psychiatric Patients, Heike Anderson-Schmidt
-The Biological Psychiatrist’s View on BrainNet Europe II (BNE), a European-Wide Associaton of Brain Banks, Peter Falkai
-”When the Entire Country is a Cohort.” Registries, Cohorts and Biobanks in Norway: Research Opportunities and Ethical, Legal and Societal Implications, Camilla Stoltenberg
-Brain Banking: Ethical Issues and Legal Solutions – The UK Experience, Shawn Harmon

Wednesday, October 17, 2012, 3:00 pm – 4:30 pm

SYMPOSIUM #9   Genome Sequencing in Bipolar Disorder
Chair/Discussant: John Kelsoe; Co-chair/Discussant: Francis McMahon

-Whole Genome Sequencing in an Unusual Family Identifies a Possible Pathogenic Variant in the NTRK1 Gene, John Kelsoe
-Whole-Exome Sequencing in Bipolar Disorder, Jimmy Potash
-The Bipolar Research in Deep Genome and Epigenome Sequencing (BRIDGES) , Margit Burmeister
-Family Genome Sequencing of Bipolar Disorder, Seth Ament

SYMPOSIUM #10   Comorbidities and Cross-disorder Analyses in Psychiatric Disorders
Chair: Manuel Mattheisen; Co-chair: Preben Bo Mortensen; Discussant: Marcella Rietschel

-Somatic Comorbidities as Clues for the Etiology of Schizophrenia, Preben Bo Mortensen
-Estimation of Variance Explained by SNPs for 5 Disorders and Estimation of Genome-Wide Pleiotropy between Them, Naomi Wray
-Causation and Causal Inference in Genetic Epidemiology, Christopher Lange
-Asthma as a Comorbidity in Psychiatric Disorders, Manuel Mattheisen

SYMPOSIUM #11   Identification and Functional Consequence of Genetic Variants Conferring Risk of Psychiatric Disease in Outcome of NEWMEDS Collaboration
Chair: Michael Didriksen; Discussant: René Kahn

-Recurrent CNVs Affecting Fecundity, Hreinn Stefánsson
-Gene-dosage Dependent Effects of a Copy Number Variant Associated with Schizophrenia Risk on Brain Structure, Andreas Meyer-Lindenberg
-A Mouse Model of 15q13.3 Microdeletion Syndrome Recapitulates Several Phenotypes of the Human Syndrome, Jacob Nielsen
-A Mouse Model of 15q13.3 Microdeletion Syndrome Display Pre-attentive Processing Deficits and EEG Phenotypes Seen in Schizophrenia, Michelle Rosgaard-Birknow

SYMPOSIUM #12   The Challenge and Future of Depression Genetics
Chair/Discussant: Gerome Breen; Co-chair: Doug Levinson

-eQTL Analysis of Glucocorticoid Regulated Gene Expression: New Insights into the Genetics of Major Depression, Elisabeth Binder
-Analysis of the Evolutionary Effects and Context of Depression, Robert Power
-Depression Genes and Networks: Combining Genotype and Gene Expression Data to Unravel Regulatory Networks Contributing to the Risk of Major Depressive Disorder, Sarah Mostafavi
-The Current State and Future of Depression Genetics, Gerome Breen